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Total 14747 results found since Jan 2013.

Baseline Metabolic Tumor Volume Measured by FDG PET/CT Before Neoadjuvant Chemotherapy Predicts Survival in Pediatric Osteosarcoma
Conclusions Initial baseline tumor PET MTV and TLG are independent predictors of EFS and OS in pediatric patients with osteosarcoma. These intriguing findings need further validation in larger prospective studies. $$graphic_DF4D573F-430B-481C-B19E-7C2B58764DDC$$ Table 1. Univariate analysis of the variables for EFS and OSVariablesP value for EFSP value for OSSUVmax0.0410.033SUVpeak0.0030.006MTV (ml)0.0020.0009TLG (g)0.00030.0001Histologic Response0.0690.047Initial presence of metastasis0.0560.026
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Im, H.-J., Wu, H., Yi, Z., Wu, J., Shulkin, B., Cho, S. Tags: Pediatric Nuclear Medicine Source Type: research

Exercise Intervention in Pediatric Patients with Solid Tumors: The Physical Activity in Pediatric Cancer Trial
Introduction: The randomized controlled trial “Physical Activity in Pediatric Cancer” determined the effects of an inhospital exercise intervention combining aerobic and muscle strength training on pediatric cancer patients with solid tumors undergoing neoadjuvant chemotherapy. Methods: Participants were allocated to an exercise (n = 24, 17 boys; mean ± SEM age, 10 ± 1 yr) or control group (n = 25, 18 boys; 11 ± 1 yr). Training included three sessions per week for 19 ± 2 wk. Participants were assessed at treatment initiation, termination, and 2 months after end treatment. The primary endpoint was muscle strength (...
Source: Medicine and Science in Sports and Exercise - January 18, 2017 Category: Sports Medicine Tags: Clinical Sciences Source Type: research

Value of dynamic magnetic resonance imaging in preoperative evaluation of pediatric osteosarcoma
Conclusions DCE-MRI can be used preoperatively as a sensitive, specific, and non-invasive method for detection of viability and necrosis within osteosarcoma.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - May 18, 2017 Category: Nuclear Medicine Source Type: research

Pediatric Nasopharyngeal Carcinoma: A Rare Tumor in a Developing Country—What Do We Learn?
Conclusions: Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy was an effective strategy in the treatment of pediatric NPC with good overall survival and event-free survival. High systemic failure (33.3%) remains another challenge to solve. More efforts should be made to improve survival by developing more efficient systemic treatment modalities, especially for progressive/relapsed disease. Multicenter studies on a larger number of patients are needed to identify different prognostic factors and standardize treatment strategies.
Source: Journal of Pediatric Hematology Oncology - March 25, 2020 Category: Hematology Tags: Online Articles: Original Articles Source Type: research

Sacrococcygeal teratoma: Clinical characteristics, management, and long-term outcomes in a prospective study from a Tertiary Care Center
Conclusions: Teratomas are the most common germ cell tumors of the sacrococcygeal region. Most of the tumors are benign, and the incidence of malignancy increases with age. The evaluation of malignancy is, therefore, necessary in these children. Excellent survival of 95% was achieved in this series. Morbidity due to associated malformation, disease recurrence, and treatment may persist in these patients; hence, proper follow-up is needed.
Source: Journal of Indian Association of Pediatric Surgeons - November 26, 2019 Category: Surgery Authors: Devendra Kumar Yadav Samir Kant Acharya Deepak Bagga Vishesh Jain Anjan Dhua Prabudh Goel Source Type: research

Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC Randomized Trial
Abstract: The purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control [n = 11] and exercise group [n = 9]). Although no significant interaction (group × time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interventions...
Source: American Journal of Physical Medicine and Rehabilitation - October 23, 2017 Category: Rehabilitation Tags: Brief Reports Source Type: research

Multimodality Treatment of Pediatric Esthesioneuroblastoma
ConclusionsPediatric ENB is a chemosensitive disease. Preoperative chemotherapy‐based multimodal approach should be used in patients with advanced stage disease. Radiation therapy is effective for local control, but lower doses should be considered in children.
Source: Pediatric Blood and Cancer - October 30, 2015 Category: Cancer & Oncology Authors: Rajkumar Venkatramani, Hubert Pan, Wayne L. Furman, Jonathan M. Marron, Josephine Haduong, Paola Friedrich‐Medina, Anita Mahajan, Abhishek Bavle, Hao Wu, Murali Chintagumpala Tags: RESEARCH ARTICLE Source Type: research

Primary mediastinal and retroperitoneal malignant germ cell tumors in children and adolescents: Results of the TGM95 trial, a study of the French Society of Pediatric Oncology (Soci été Française des Cancers de l'Enfant)
ConclusionIn children with mediastinal or RP GCTs, the prognosis is favorable when a strategy of delayed aggressive surgery is performed after cisplatin‐based chemotherapy. Younger patients have a better prognosis. Relapses were observed only in adolescents and could not be cured.
Source: Pediatric Blood and Cancer - March 17, 2017 Category: Cancer & Oncology Authors: H élène Sudour‐Bonnange, Cécile Faure‐Conter, Hélène Martelli, Frederic Hameury, Brice Fresneau, Daniel Orbach, Cécile Vérité Tags: RESEARCH ARTICLE Source Type: research

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric ovarian tumors: a novel treatment approach
Conclusions This is the first report of CRS and HIPEC in pediatric ovarian tumors. HIPEC may be effective in pediatric-type ovarian tumors. More study is needed in a larger cohort.
Source: Pediatric Surgery International - October 25, 2015 Category: Surgery Source Type: research

Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
The management of pediatric abdominopelvic angiosarcoma remains unclear due to limited clinical experience. Herein, we presented the first 2 pediatric patients with abdominal angiosarcoma who were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) after neoadjuvant therapy. The first patient is alive with recurrent disease at 1-year follow-up and the second patient remains disease free after 1 year. CRS and HIPEC should be considered as a therapeutic option in the management of pediatric abdominal angiosarcomas. A multi-institutional international shared registry is needed to fur...
Source: Journal of Pediatric Hematology Oncology - October 23, 2018 Category: Hematology Tags: Online Articles: Original Articles Source Type: research

Pediatric oncofertility care in limited versus optimum resource settings: results from 39 surveyed centers in Repro-Can-OPEN Study Part I & amp; II
ConclusionsBased on Repro-Can-OPEN Study Part I& II, we presented a plausible oncofertility best practice model to help optimize care for children with cancer in various resource settings. Special ethical concerns should be considered when offering advanced and innovative oncofertility options to children.
Source: Journal of Assisted Reproduction and Genetics - December 21, 2022 Category: Reproduction Medicine Source Type: research

Pediatric adenoid cystic carcinoma of the lacrimal gland treated with intra-arterial cytoreductive chemotherapy
We report the first known pediatric case of ACC treated with IACC, followed by exenteration, radiation, and adjuvant intravenous chemotherapy. The patient was followed for 4 years, with no recurrence and no known complications.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - April 30, 2015 Category: Opthalmology Source Type: research

Clinical outcome and morbidity in pediatric patients with nasopharyngeal cancer treated with chemoradiotherapy
ConclusionsTreatment with neoadjuvant chemotherapy followed by concurrent chemoradiation provides good survival outcomes in pediatric NPC. The quality of life of the survivors is a pertinent area that necessitates consideration.
Source: Pediatric Blood and Cancer - September 28, 2016 Category: Cancer & Oncology Authors: Puja Sahai, Bidhu Kalyan Mohanti, Atul Sharma, Alok Thakar, Suman Bhasker, Aanchal Kakkar, Mehar Chand Sharma, Ashish Datt Upadhyay Tags: Research Article Source Type: research

Long-term outcomes of pediatric and adolescent mediastinal germ cell tumors: a single pediatric oncology institutional experience
ConclusionsInitial surgical resection is appropriate for teratomas. Localized disease, complete resection, and platinum-based chemotherapy are associated with improved survival in malignant non-seminomatous mediastinal germ cell tumors. Neoadjuvant, platinum-based three drug regimens followed by delayed surgical resection is the appropriate treatment modality for malignant mediastinal germ cell tumors.
Source: Pediatric Surgery International - November 11, 2016 Category: Surgery Source Type: research